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Chen Guangyu Dongzhitang Pharmaceutical (Anhui) Co., Ltd.
The pulverization of traditional Chinese medicine is mainly to use mechanical force to turn large solid medicinal materials into suitable solid particles to increase the surface area of ​​the operation process. Since large solid drugs (or roots, stems, leaves and fruits of Chinese herbal medicines) cannot be directly formulated and cannot effectively perform their functions, it is necessary to carry out a pulverization operation to obtain solid particles of a certain size to ensure the stability of the manufactured drugs. And effectiveness, so drug comminution is an important and essential unit operation of traditional Chinese medicine engineering.
When selecting the pulverizing equipment according to the process and environmental requirements, the following points should be noted: (1) the amount of treatment; (2) the particle size and particle size distribution requirements of the pulverized drug. Different dosage forms require different particle size distribution; (3) there should be no metal and other impurities in the pulverized medicine; (4) high requirements for pulverization control and environmental sanitation, and should comply with GMP; (5) temperature control in the pulverizer Strict, especially for heat-sensitive herbs and flammable and explosive materials; (6) Some drugs have high toughness, high viscosity, oil and water, and difficult to smash.
Stately Zhengzhou Sheng Pharmaceutical Co., Ltd. The total process <br> <br> select from the viewpoint of the following aspects: the characteristics (1) to be pulverized material, the process required fineness; (2) single or crushed medical herb flavor Mixing and smashing the medicinal materials; (3) extracting the extracts separately and pulverizing them separately or mixing them with other materials; (4) mixing the raw powders with the extracts after drying; (5) pulverizing requirements for special materials; (6) matching yields; 7) Microbial limit requirements.
From the environmental requirements, we should choose from the following aspects: (1) suitable site conditions; (2) vibration and noise; (3) different purification requirements for direct or intervening drugs; (4) dust collection and post-processing; ) Local environmental requirements.
Select the Deputy Minister Sun Kaiming Nanjing Tongrentang Pharmaceutical Co., Ltd. Engineering <br> <br> crushing instrument should be based on characteristics of the crushed material, in particular its hardness and ease of rupture is selected. If the smashing of the harder drug is selected, the effect of the device on the impact force and the squeezing force is good. If the hard and valuable drug is pulverized, the boring device or the ball mill may be used; if the smashing toughness or the brittle drug is used, It is advisable to select an impact mill.
Specifically, it can be considered from the following aspects: (1) product specifications (particle size range, particle size distribution, shape, moisture content); (2) production capacity of crushing equipment and requirements for production speed; (3) adaptability of operation (wet Method grinding and dry grinding, pulverization speed and screen replacement time, safety situation); (4) dust control (loss of valuable drugs, health hazard, pollution to the factory); (5) environmental sanitation (easy to clean) (6) auxiliary equipment (cooling system, dust collector, forced feeding, graded crushing); (7) batch or continuous operation; (8) economic factors (power consumption, floor space, labor costs) . It should also be noted that in the purchase and configuration of the machine, it should be considered that the structure is simple, easy to clean and easy to repair. When the new machine is tested after installation, the cover must be opened to check for any debris, and whether the fixed parts are loose and rotated. Spindle pulley to see if the rotation is flexible and there is no impact sound. After the inspection is completed, there is no bad phenomenon, and the idling can be carried out first. The idling time is not less than 15 minutes, and it can be used without any trouble after the Zui.
Xiao Jieming, Director of Hangzhou Chunjiang Automation Research Institute
According to the powder size, the Chinese medicine can be divided into coarse crushing, fine crushing, and ultrafine crushing. Among them, the fine pulverization should be carried out before the ultrafine pulverization, and the coarse pulverization should be carried out before the micro pulverization, and the pulverization ratio should be no more than 20 mesh. The selection of the pulverizing equipment is mainly selected according to the powder size requirement and the characteristics of the medicinal material. Commonly used coarse crushing equipments include jaw crushers and roller crushers, which are mainly used for rough processing of hard botanicals and most mineral medicines. Commonly used micro-grinding equipments include hammer mills and impact mills, which are suitable for crushing below 200 mesh. Commonly used superfine grinding equipments include ball mills, vibrating mills and jet mills, which are suitable for crushing above 200 mesh. The micro-grinding and ultra-fine grinding equipment is suitable for the pulverization of most medicinal materials. However, the pulverization of the medicinal materials containing sugar powder should be carried out by freeze pulverization. The fibrous medicinal materials should be coarsely crushed before being pulverized, and then finely pulverized and ultra-fine pulverized. .
Lin Yanhai Yunnan Bio Valley Denghuahua Pharmaceutical Co., Ltd.
(1) Excessive pulverization, excessive destruction of the cell wall of the extract, so that more impurities are precipitated during extraction; (2) According to the nature of the material to be pulverized, the particle size requirements of the product, combined with the use of the pulverizing equipment The pulverized form selects the pulverizer. For example, the crushing process of the universal pulverizer generates heat, so it is not suitable to pulverize a medicinal material containing a large amount of volatile components, a viscous medicinal material, and a softened material after being heated.
From the perspective of materials research, Chinese medicine can be divided into plants, animals and minerals. Mineral Chinese medicines such as keel and magnet are inorganic non-metallic mineral materials. The pulverization method and pulverization mechanism are the same as the ultrafine pulverization mechanism of non-metallic minerals; animals such as whole insects, scorpions, etc., after drying (or lyophilization) Smash it. Since animals contain a lot of fat, smashing is difficult; plants such as ginseng, notoginseng, medlar, etc. must be treated separately according to the actual situation, and the fineness of pulverization can generally be from 3 to 5 μm to 40 to 50 μm. The pulverizing means are mechanical pulverization, eddy current pulverization, vibration grinding, and airflow pulverization, respectively. Most of the traditional Chinese herbal medicines crushed by mechanical pulverization can meet the requirements of the production process of pills, powder, paste and dan.
The methods for superfine pulverization of traditional Chinese medicine include mechanical pulverization, vibration pulverization, and airflow pulverization. Among them, the mechanical pulverization fineness can reach 80 mesh, and the adjustment of the pulverization fineness is controlled by the screen of the inner cavity of the device. The vibration mill pulverization can be used on the ultrafine pulverization of the traditional Chinese medicine, and the pulverization fineness is between 1 and 40 μm. The difference between jet pulverization and the above pulverization is that the pulverized material is impact pulverized by high-speed airflow, and the pulverization fineness can reach 1 to 10 μm, or even less than 1 μm, which is also capable of achieving physical fine processing of fineness. method.
Wei Zengyu, Engineer of the Pharmaceutical Preparation Training Center of Lianyungang Chinese Medicine Higher Vocational and Technical School
The smashing of traditional Chinese medicine is a hygienic requirement that is easy to be neglected in management. Some enterprises have a combination of raw medicine smashing and net medicine smashing, and there is no separation, or in order to save equipment costs, using the same equipment, it is easy to cause pollution and cross-contamination. Therefore, in the cleaning of the net medicine, attention should be paid to the selection and installation of the equipment. The equipment should be simple in structure, convenient in operation and easy to clean. Pay attention to the reasonable layout of the console, machine room and powder collection room during installation, and avoid noise of the equipment. For the damage to the human body, it is also necessary to observe and control the operation of the equipment, which is beneficial to the equipment operators to properly use and maintain the equipment. When designing the plant, it is important to consider the requirements of dust removal, ventilation, and cleaning. Comprehensive consideration can improve the efficiency of equipment utilization.
Many experts talk about the process and environment of Chinese medicine crushing equipment
The smashing of Chinese medicine is a crucial part. How to choose the crushing equipment according to the process and environmental requirements?