[Front] Saliva diagnosis of cancer: from science fiction to reality!

In May 2015, at a dinner in Guangzhou, Liao Wei and his senior high school students chatted about the situation. At that time, Liao Wei had just founded Yi Living in Guangzhou.

● Chairman of Yi Huo Bio, Liao Wei ●

He once served as the vice president of strategic planning for AQS, the largest electronics design and manufacturing company in Silicon Valley, USA. Later, at the founding of Huaxing Capital, he saw many hardware innovation projects in Silicon Valley. Entrepreneurship seems to be a reality for Liao Wei.

However, it is not easy to get started. At that time, Liao Wei held only one innovative technology brought from the United States. There were no managers, and even the R&D team was vacant.

At this time, the old classmates who worked for a certain regional executive of China Telecom had already experienced burnout in the traditional industry. The innovative technology that Liao Yi talked about made him very curious.

What kind of innovative technology does he bring?

The listening name is very common - early diagnosis of lung cancer (ctDNA diagnosis), but it is very special:

First of all, the sample can be not only blood, but also a tube of saliva!

In addition, they do ctDNA detection without extraction and amplification!

However, why did you choose to test saliva samples? Other companies are doing blood test products!

This is a historical reason. Liao Wei’s big project in UCLA in the United States was to use saliva for the diagnosis of systemic diseases.

Saliva is equivalent to the ultrafiltrate of blood. It filters out cells and macromolecules. Once the mucin is removed, it is the same as clear water, so it is relatively pure and better tested.

In addition, after doing hundreds of clinical trials, they found that the sensitivity and specificity of saliva detection are 100%, higher than blood tests, and the results of tissue biopsy are exactly the same, and the sample size required is only 50 micro. Rise.

Since it is so easy to use, why are the products and platforms of other companies not doing saliva testing?

In fact, there are many small pieces of tens of BP in saliva. Most of the detection of the platform now needs to be amplified by PCR. The amplification will limit the length of the gene fragment. The minimum length that can be detected may be 80 BP or even 100 BP. The easy-to-live method is to detect only the segment of the mutation and does not require amplification, so that fragments below 60 BP can be detected.

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