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In the mid-80s of the last century, people only identified a small number of instruments such as gene amplification instruments (PCR), nucleic acid protein analyzers, microplate readers, cell detectors, and biochemical analyzers as life science instruments. Today, except In addition to the instruments included in the narrow definition, scientists have identified four basic instruments (ultraviolet-visible spectrophotometer, atomic absorption spectrophotometer, liquid chromatograph, gas chromatograph) as the backbone of life science instruments; Chromatography, mass spectrometry, and related techniques are called life science instruments. At present, the definition of life science instruments is becoming more and more clear, and the "Live Scince Instrument" is a prominent term in many literatures. More and more scientists around the world recognize "Live Scince Instrument"
1. At present, life science instruments are gradually developing in a new direction from the original low speed, slow, and poor performance. "Three Super" is the current trend of the development of life science instruments. The so-called "three super" refers to: ultra-high speed, ultra-micro and ultra-small.
(1) Ultra-high speed <br>The world's fastest DNA synthesizer, which can synthesize one base in 2 minutes; 2 hours of work efficiency, equivalent to 4-5 years of manual work by 25 professionals. That is, its 1 hour workload is equivalent to 90,000 hours of manual work by people. In other words, work efficiency has increased by 90,000 times. It can be said that the DNA synthesizer is a model for the development of life science instruments to ultra-high speed.
It is particularly noteworthy that the time-resolved fluorescence immunoassay (DEFIA) introduced by Phamacia in Sweden in recent years can analyze one sample per second and analyze 3,600 samples per hour with a sensitivity of 10-17 mol(Eu). This is another example of the development of a life science instrument towards ultra-high speed.
In 2006, Shimadzu, Japan introduced ultra-fast liquid chromatography (UFLC), which took only 10 seconds to inject and 10 times faster. These are all one of the latest developments worth noting. U.S. Waters has introduced ultra-high pressure liquid chromatography (UPLCTM) in recent years with a maximum operating pressure of 15,000 psi, which greatly increases the speed of analysis without reducing the resolution. This kind of instrument is worthy of attention by science and technology workers.
The MB5 atomic absorption spectrophotometer launched by Beijing Pu's General Motors Co., Ltd. in recent years, a five-element lamp, a drop of blood, can simultaneously obtain the results of five elements of Cu, Zn, Ca, Mg, and Fe. One of the developments worthy of attention.
(2) Ultra-micro
Atomic Absorption Spectrophotometer (AAS) is one of the most developed analytical instruments in recent years with detection limits of 10 - 13 g. With the development of science and technology and the changing environment of human beings, the application of AAS will become more and more extensive. In recent years, international scientists have discovered that many rare elements are strong carcinogens. The American Cancer Research Center reports that 90% of human cancers are derived from organic matter (including trace amounts of heavy metals). The detection of heavy metal elements mainly uses AAS, so it develops very quickly. For example, in 2006, Jena of Germany officially launched the ContruAA continuous light source AAS, which can analyze more than 60 elements. It has been produced in small batches. Because of the general conventional AAS, one element lamp can only analyze one sample. So it should be said that the Jen ContruAA continuous light source AAS from Germany is a revolutionary breakthrough for AAS.
Also, the atomic fluorescence photometer is an analytical instrument invented in China, and several companies in China have produced such instruments. In 2005, Beijing Ruili Company launched the AF-630/640 environmentally-friendly multi-channel atomic fluorescence photometer, which has 8 independent intellectual property rights. It is a good life science analysis instrument and it is worthy of your attention.
(3) Ultra-small <br> Ultra-small ultra-small, ultra-small, ultra-small, ultra-small, it is very difficult to achieve on the same instrument. However, contemporary life science research work and many household analytical instruments often hope that the "three supers" can be realized on the same instrument, which requires the instrument to be stable and reliable, and requires ultra-small, small, and portable. Therefore, in recent years, there have been many ultra-small life science instruments such as a water quality analyzer that can be put into a teacup, a glucose detector that can be put in a pocket, and the like. As we all know, UV-visible spectrophotometer is an indispensable analytical tool in life science research, and it has been recognized as one of the backbone products of life science instruments.
2 Rapid development of joint technology <br>The development of modern scientific instruments is closely related to the breakthrough of methodology. Often a breakthrough in a new method will lead to the development of a large number of disciplines, and the development of life science instruments can be said to be a typical example. We can say that the development of new joint technology is a major feature of the development of life science instruments; often a method, an analytical test problem in the field of life science that cannot be solved by one instrument, several methods or several instruments Use, the problem will be solved.
Common combination techniques such as the combination of FIA and atomic absorption spectrophotometer (AAS), the combination of AAS and H PLC, and the use of various combined instruments make the difficult problem more simple and difficult. Complex words. The development of joint technology can be said to be a milestone development.
The following are sales of excellent life science instrument manufacturers.
The combination of Thermo Electron and Fisher Scientific has greatly increased the sales of its products, and the sales performance has improved significantly. In terms of liquid and gas, Agilent and Shimadzu still dominate. In addition, Becton Dickinson, Varian, GE Healthcare BioScience, Hatachi and JEOL, as well as Invitrogen, Spectris pic, Smiths Detection and Mettler-Toledo also have good sales.
It is true that the gap between domestically produced instruments and foreign brands in life sciences is still great, but science is the world, belongs to us humans, and hopes that more people will make more high-quality experiments. At the same time, the development of our domestically produced instruments must be redoubled.
Analysis of the latest development trend of life science instruments
With the development of science and technology, humans and living things are facing increasingly serious environmental and ecological problems. According to the American Cancer Research Center, 90% of human cancers come from organic matter, mainly pesticides and their residues. Therefore, seriously studying the issues of human life, survival, development, ecological balance, and environmental protection is a global and urgent problem that needs to be solved in the contemporary and future years. To study human life, survival, development and ecological balance, environmental protection and other issues, we must have relevant life science instruments. Otherwise, nothing will happen. This is the inevitability of the development of life science instruments. At present, life science instruments have involved disciplines such as analytical chemistry, biomedicine, laboratory technology, and bioengineering.