Stevia sweeteners are derived from the leaves of the Stevia rebaudiana (Bertoni) plant, an herbal shrub native to South America. The stevia plant has been used for food and medicinal purposes for hundreds of years, and its leaves and crude extracts have been sold as dietary supplements. Purified extracts of the sweet substances found in the stevia leaf, called steviol glycosides, are considered to be generally recognized as safe (GRAS) by the U.S. Food and Drug Administration (FDA). However, whole stevia leaves and crude leaf extracts are not permitted to be sold as sweeteners in the U.S. because there is not enough toxicological information on these products, according to the FDA. Stevia sweeteners are made by extracting steviol glycosides from the leaves of the stevia plant and purifying them to remove some of the bitter attributes found in the crude extract. Stevia JINING USP INTERNATIONAL CO.,LTD. , https://www.uspintl.com
Talking about Haier Cold Chain Temperature Monitoring System
Talking about Haier Cold Chain Temperature Monitoring System
First, why should we develop a cold chain monitoring system?
At present, the information control system is widely used in the disease control system, blood station, and hospital system, which greatly improves the safety of blood, reagents, and vaccines, and establishes operational specifications that comply with the implementation rules. However, the temperature monitoring system of cold chain equipment has not yet been obtained. Adequate attention, the vaccine and blood quality problems that have occurred have been shocking, and temperature monitoring of all aspects of cold chain equipment is imperative.
We often see from the media news reports that temperature-sensitive drugs, blood, and vaccines cause significant personal accidents and economic losses due to the lack of effective cold chain logistics management during production and transportation. Such as "Shanxi high temperature vaccination incident", "Jiangsu rabies vaccine incident" and other events. In these vaccine events, there are cases where the vaccine is not transported as required during refrigeration. Vaccine cold chain transport chain scission, resulting in vaccine failure. Without exception, it has brought huge economic losses and negative social impacts.
In response, the Chinese government has introduced relevant food safety regulatory laws and regulations to regulate the management of the cold chain supply chain. For example: 1. On April 19, 2005, the State Council also promulgated the Regulations on the Administration of Vaccine Circulation and Vaccination. 2. The Ministry of Health and the State Food and Drug Administration issued a joint notice in June 2010, requesting local governments to organize 2010 national vaccination work, increase supervision of vaccine production and wholesale enterprises, and strengthen vaccine circulation and cold chain operation management. To ensure that the vaccine storage and transportation links are in the cold chain. 3. The "Good Manufacturing Practices for Pharmaceuticals" clearly stipulates that enterprises that operate vaccines or biological products should have refrigerated (frozen) storage and transportation equipment that are compatible with the scale of operations and business varieties; during transportation, there are temperature requirements. For drugs, the corresponding insulation or refrigeration measures shall be adopted; the refrigerated vehicles and refrigerated (freezing) boxes used for vaccine transportation shall be able to automatically regulate and display the temperature conditions; the drug transportation shall be completed within the prescribed time, and the transportation vehicles shall not be used as medicines. Storage location. The whole process of production, storage, transportation, distribution and use of vaccines for immunization should have intact refrigeration equipment so that the vaccine is always placed in the prescribed temperature environment to ensure that the efficacy of the vaccine is not affected. The cold chain equipment includes low temperature cold storage for storage of vaccines, ordinary cold storage, vaccine transport vehicles, refrigerators, refrigerators, refrigerated backpacks and monitoring systems.
At the present stage, China still lacks effective management methods for food and drug cold chain logistics. The original monitoring technology is lagging behind is the biggest technical bottleneck. At present, the main crux of China's technical means are: manual measurement and paper recording; no unified data system support; poor real-time performance, disjointed supervision; difficulty in obtaining evidence, uncertainty in determining; failure to provide early warning and large loss rate. Because blood products, reagents, and vaccines have strict requirements on the storage environment, any abnormal temperature changes may have a serious impact on the quality of blood products, reagents, and vaccines. At the same time, storage devices are scattered, large in quantity, and require high precision, while artificial It is impossible to record and observe temperature changes every moment, so it is very important and urgent to establish an automated temperature monitoring, recording and early warning system for cold chain equipment.
Second, the third generation of cold chain monitoring system that is currently escorting user vaccines, blood, etc.
  A series of products, such as intelligent temperature acquisition module, intelligent temperature and humidity acquisition module, intelligent temperature recorder, developed by Qingdao Haier Special Electric Co., Ltd., require advanced temperature management through advanced temperature sensing technology. In order to ensure the quality of temperature-sensitive drugs, blood, vaccine logistics management and production process management, the temperature and humidity of the product are managed in real time. It can easily and easily solve the deterioration of temperature-sensitive drugs, blood and vaccines in circulation and storage, and realize real-time monitoring and alarm of temperature and humidity. Maximize the quality of temperature sensitive drugs, blood, vaccines and other products.
At present, Haier cold chain monitoring system has escorted most blood stations, blood centers, hospitals, disease control systems, scientific research units of major universities, biopharmaceutical units, etc., and has realized internal and external units, (provincial and municipal levels). , county level) unit temperature monitoring of the upper and lower levels, while Haier cold chain monitoring system brings the following value to users:
1. Through the real-time monitoring of the temperature of the cold chain equipment and the query function of the historical record, the user's concern about the temperature stability of the cold chain equipment is solved;
2, through the cold chain equipment temperature over-temperature SMS alarm, let users know the operation of the equipment at the first time, to ensure the safety of blood, vaccines, drugs, truly achieve worry-free work, no worries after work;
3. Through the report statistical analysis function of the cold chain monitoring system, on the one hand, it solves the problems of large workload caused by the user's daily work report due to the manual recording; on the other hand, it solves the difficulty of collecting the user's phased temperature data and summarizes Quasi-equal problem;
Third, why should we develop the fourth generation cold chain monitoring system?
1. The third generation of cold chain monitoring system 8 intelligent acquisition modules are equipped with one relay module as standard, and the intelligent acquisition of the transmitted signal is limited. The effective receiving distance of the relay module is about 50 meters. Due to the limitations of the product, the user is caused. The cost of purchasing and configuration is improved; the fourth-generation cold chain monitoring system changes the communication protocol, and one unit monitors only one network concentrator, and wirelessly connects multiple collection terminals. A separate network can connect 254 collection terminals, and the concentrator is effective. The receiving distance is close to 3000 meters. The wireless network has the functions of intelligent networking, cascade transmission, intelligent routing, intelligent route recovery, etc., which breaks the limitation of the third generation signal transmission distance;
2. The third-generation intelligent acquisition module does not have the temperature display function. The user calls it the black box. The fourth generation cold chain monitoring system intelligent acquisition module can display the real-time temperature information.
3, the third generation of intelligent temperature recorder only has a short message transmission mode, once the amount is large, it can generate a large amount of SMS charges; the fourth generation of intelligent temperature recorder adds GPRS module, the user can purchase according to the specific situation;