99% Antitumor Pharmaceutical Material Ap26113 CAS 1197958-12-5

October 29, 2018

Model NO.: 1197958-12-5
Trademark: XXJLHGH
Transport Package: Foil Bag or Drums
Specification: 1kg
Origin: China
HS Code: 3913900000
Model NO.: 1197958-12-5
Trademark: XXJLHGH
Transport Package: Foil Bag or Drums
Specification: 1kg
Origin: China
HS Code: 3913900000
99% Antitumor Pharmaceutical Material Ap26113 CAS 1197958-12-5

Basic Info
Name:AP26113
CAS:1197958-12-5
Molecular Formula:C27H36ClN6O4P
Molecular Weight:575.039301
Color:White powder
Purity:98%min
Usage: Pharmaceutical Intermediates
Related Categories:Signal transduction pathway kinase inhibitor; cell signaling pathway inhibitor; protein tyrosine kinase; pharmaceutical intermediates; API; small molecule inhibitors; small molecule inhibitors, natural products
Packaging Details:on request
Delivery Detail:Shipped in 3 days after payment

Description
AP26113 is an effective ALK inhibitors, IC50 was 0.62 nM, can overcome due to the effect of Crizotinib resistance of the mediated L1196M mutations. AP26113 highly effective on the sensitive and resistant H3122 cells, reduce the cell growth, inhibition of ALK, phosphate and induction of apoptosis, this effect is dose dependent. Applied to H3122 AP26113 and H3122 CR cells, reduce p - ALK, IC50 were 7.4 and 16.8 nM. AP26113 role in expressing wild-type and mutant EML4 - ALK Ba/F3 cells, reduce the cell number, 24 nM to 10 nM and IC50 respectively.

 
Anticancer
Azd-9291 Mesylate/Osimertinib 1421373-66-1 XL-184 Malate/Cabozantinib Malate 1140909-48-3
E7080 Mesylate/Lenvatinib Mesylate 857890-39-2 AZD6244/ Selumetinib 606143-52-6
AZD3759 1626387-80-1 INC280/Benzamide 1029712-80-8
Vemurafenib 918504-65-1 Neratinib 698387-09-6
Dabrafenib Mesylate 1195768-06-9 Olaparib 763113-22-0
MK1775 955365-80-7 Crizotinib 877399-52-5
AP26113 1197958-12-5 LY 2157299/Galunisertib 700874-72-2



  99% Antitumor Pharmaceutical Material Ap26113 CAS 1197958-12-5

Basic Info
Name:AP26113
CAS:1197958-12-5
Molecular Formula:C27H36ClN6O4P
Molecular Weight:575.039301
Color:White powder
Purity:98%min
Usage: Pharmaceutical intermediates
Related Categories:Signal transduction pathway kinase inhibitor; cell signaling pathway inhibitor; protein tyrosine kinase; pharmaceutical intermediates; API; small molecule inhibitors; small molecule inhibitors, natural products
Packaging Details:on request
Delivery Detail:Shipped in 3 days after payment

Description
AP26113 is an effective ALK inhibitors, IC50 was 0.62 nM, can overcome due to the effect of Crizotinib resistance of the mediated L1196M mutations. AP26113 highly effective on the sensitive and resistant H3122 cells, reduce the cell growth, inhibition of ALK, phosphate and induction of apoptosis, this effect is dose dependent. Applied to H3122 AP26113 and H3122 CR cells, reduce p - ALK, IC50 were 7.4 and 16.8 nM. AP26113 role in expressing wild-type and mutant EML4 - ALK Ba/F3 cells, reduce the cell number, 24 nM to 10 nM and IC50 respectively.

 
Anticancer
Azd-9291 Mesylate/Osimertinib 1421373-66-1 XL-184 Malate/Cabozantinib Malate 1140909-48-3
E7080 Mesylate/Lenvatinib Mesylate 857890-39-2 AZD6244/ Selumetinib 606143-52-6
AZD3759 1626387-80-1 INC280/Benzamide 1029712-80-8
Vemurafenib 918504-65-1 Neratinib 698387-09-6
Dabrafenib Mesylate 1195768-06-9 Olaparib 763113-22-0
MK1775 955365-80-7 Crizotinib 877399-52-5
AP26113 1197958-12-5 LY 2157299/Galunisertib 700874-72-2



 

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