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China successfully developed the world's first high-compensation depth living human retinal imaging system
On June 30, 2008, a groundbreaking development in medical imaging was announced. China has successfully created the world's first high-compensation depth living human retinal imaging system—known as the high-definition fundus imaging liquid crystal aberration compensator. This innovative technology was recently evaluated and approved by a panel of experts organized by the Science and Technology Department of Jilin Province in Changchun. The research was led by Xuan Li, a researcher at the Changchun Institute of Optics and Mechanics, Chinese Academy of Sciences.
The retina is a critical part of the eye, composed of ectodermal nerve tissue, while its blood vessels originate from the mesoderm. These vessels are unique in that they are the only small blood vessels in the body visible directly without invasive procedures. Fundus examinations are widely used to detect systemic conditions such as cardiovascular diseases, diabetes, hypertension, and neurological disorders. As a result, this type of imaging plays a vital role not just in ophthalmology, but also in assessing overall health and disease progression.
Traditional fundus imaging equipment typically resolves details down to about 20 micrometers, but the smallest blood vessels in the eye are as narrow as 5 micrometers. To address this challenge, Xuan Li’s team embarked on a three-year project funded by Jilin Province’s high-tech initiative. They developed a 260,000-drive-unit liquid crystal wavefront corrector, enabling high-resolution imaging of visual cells down to 3 micrometers. This breakthrough allows for precise correction of severe myopia (up to 800 degrees) and astigmatism (up to 200 degrees), significantly improving diagnostic accuracy.
Experts who reviewed the technology praised its ability to capture detailed images of even the tiniest blood vessels. The device’s liquid crystal corrector offers consistent resolution across a wide range of refractive errors. Its non-invasive nature makes it ideal for routine health screenings, potentially aiding in early disease detection. Additionally, the system could revolutionize research into retinal and neural stem cell transplantation, offering new ways to study and treat blindness.
Currently, the system is undergoing clinical trials and is on the verge of commercialization. With full intellectual property rights, the technology is expected to gain widespread adoption. Jilin Province has pledged strong support for its development, signaling a major step forward in medical imaging and healthcare innovation.